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Sleep, Health

Sertraline And Melatonin For Improved Sleep And Mental Well-being

- Written By

Abdullah Adil

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This article is based on scientific evidence, written by experts and fact checked by experts. Our team of experts strive to be objective, unbiased, honest and to present both sides of the argument. This article contains scientific references. Read more about our process.

Sertraline And Melatonin

Doctors often prescribe two drugs for diverse medical disorders is sertraline and melatonin. Melatonin, a hormone that regulates the sleep-wake cycle, treats sleep disorders, while sertraline, an antidepressant, treats depression, anxiety disorders, and obsessive-compulsive disorder. This article covers the definitions, medical applications, mechanisms of action, adverse effects, safety considerations, and joint use of sertraline and melatonin.

Are you still wondering if you can use melatonin and Zoloft together? On one hand, sertraline being a medicine that is used to deal with depression, hypertension diseases, or psychological disorders. Meanwhile, melatonin is a medication that is used to synchronize rhythms in your body and medicate your sleep cycle.

If you take these two drugs simultaneously, will it bother you? Will it cause any kind of harm or destroy your health cycle? All of your questions are answered here with full accuracy and precise information.


First we need to know what sertraline basically are and what they are used for.

Sertraline is a derivative form of Zoloft. It is a medication utilized for the treatment of  diseases like premenstrual dysphoric disorder, an extreme form of premenstrual syndrome, panic disorders, obsessive compulsive disorder, post-traumatic stress syndrome, social phobia disorder, and anxiety . Your mental state, sleeping habits, cravings, and metabolism may all be enhanced by this medicine, which may also help you regain enthusiasm for regular activities.

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It might lessen nervousness, dread, unwelcome thoughts, and panic attacks. Premenstrual dysphoric disorder symptoms like fluctuating emotions, bloating, irritation, and discomfort in the breasts are also treated with Zoloft.

This medication belongs to the SSRI (selective serotonin reuptake inhibitor) category of antidepressants. Serotonin, a naturally occurring chemical, is increased in the brain as a result of the treatment.

1) Medical uses of sertraline

Sertraline is used to treat the main conditions of depression and anxiety disorders such as post-traumatic stress disorder (PTSD), social anxiety disorder, and panic disorder. It is also used to treat conditions such as premenstrual dysphoric disorder (PMDD) and obsessive-compulsive disorder.

2) How sertraline works?

Sertraline raises the brain’s serotonin levels, aiding in mood regulation. It prevents serotonin from being reabsorbed, allowing it to stay in the synapses between neurons for longer periods of time. This action enables the brain to access more serotonin, which may lessen the symptoms of anxiety and sadness.

3) Side effects and precautions

As adverse effects, Sertraline can produce nausea, diarrhea, headache, sleeplessness, and dizziness. In rare circumstances, it may also cause sexual dysfunction. Before beginning Sertraline treatment, it is critical to consult with your doctor about any potential adverse effects. Combining Sertraline with certain drugs, such as monoamine oxidase inhibitors (MAOIs), can result in serotonin syndrome, a potentially fatal disease.


The pineal gland, an insignificant organ in your cerebral cortex, is primarily responsible for producing the hormone melatonin, which you can say is a biological hormone. The pineal gland is a component of the endocrine system that you have.

Although the complete effects of melatonin on individuals are not yet fully understood, the majority of study evidence indicates that it promotes synchronization of circadian cycles in many sections of the human anatomy. Circadian rhythms are 24-hour cycles in one’s mental, physiological, and behavioral therapy state.

Melatonin is a very famous insomnia medication that can also be called an over the counter sleep medicine. In accordance with National Health Statistic Reports, lots of Americans presumably use it each year. It is widely used and openly available.

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1) Medical uses of melatonin

People generally use melatonin as a sleep aid, especially those who struggle to get or stay asleep. It can also help with jet lag and other sleep issues

2) How melatonin works?

Melatonin regulates the sleep-wake cycle. It is created by the pineal gland in reaction to darkness and aids in the promotion of sleep. Melatonin pills may assist those who have trouble sleeping control their sleep-wake cycle.

3) Side effects and precautions

Using Melatonin as advised is generally considered safe, although it might induce dizziness, nausea, and headaches in some people. It may also cause drowsiness, so it is essential to avoid driving or operating heavy machinery after taking Melatonin. Before using Melatonin, particularly if you are pregnant or breastfeeding, it is also crucial to consult your doctor.

Sertraline and melatonin

Patients can use sertraline and melatonin combined to treat depression, anxiety, and sleep difficulties. The combination may be especially helpful for those who have trouble falling asleep due to worry or despair. However, it is critical to consult with a doctor before using them together.

1) Combined use of sertraline and melatonin

Sertraline and melatonin promote greater mental wellness and sleep in distinct ways. Sertraline regulates serotonin levels in the brain, whereas melatonin regulates the sleep-wake cycle. People who combine these drugs may experience increased sleep quality and reduced feelings of depression and anxiety.

2) Effectiveness of combining sertraline and melatonin

Several studies have indicated that combining sertraline and melatonin for the treatment of depression, anxiety, and sleep disturbances is helpful. In 2017, the Journal of Psychiatric Research published a study that discovered that combining sertraline with melatonin significantly improved sleep quality and reduced depression symptoms in patients with major depressive disorder.

In addition, a 2018 study published in the Journal of Affective Disorders found that combining sertraline with melatonin enhanced sleep quality and reduced anxiety symptoms in patients with GAD.

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3) Precautions when using sertraline and melatonin together

Users should use sertraline and melatonin with caution, even though the combination of these drugs may be helpful for some people. They should consult with their healthcare physician before mixing these medications, especially those already taking other drugs since the combination of sertraline and melatonin may interfere with them. Users should also be aware of the potential side effects of these drugs, which include dizziness, sleepiness, and nausea.

4) Observation

Sertraline and melatonin may be an effective combo for boosting mental health and sleep quality. While additional research is needed to properly understand the advantages and potential hazards of combining these drugs, preliminary findings are encouraging.

Lets see the experience of Sarah Elizabeth with zoloft i mean sertraline and melatonin

Source / Sara Elizabeth

Comparison of Sertraline and Melatonin and Zoloft therapies on tinnitus! A clinical trial

1) What is tinnitus?

Tinnitus affects nearly 10% of the general population, causing the perception of noise or ringing in the absence of external acoustic stimuli. Various therapies have been suggested, including dietary changes, natural cures, and pharmaceutical medications.

Melatonin and zoloft, such as sertraline, are the most commonly used medications for treating tinnitus and have been confirmed in several studies. We aimed to assess the efficacy of melatonin and sertraline in treating tinnitus for the first time.

2) Method

In this clinical experiment, we randomly assigned 100 patients with tinnitus to one of two groups: the melatonin group, which took 3 mg of melatonin once daily, and the sertraline group, which took 50 mg of sertraline once daily for three months. We administered a Tinnitus Handicap Inventory (THI) questionnaire to every patient before and after therapy and evaluated the intensity of tinnitus. Then, we analyzed the data.

3) Results

The mean THI score before treatment was 45.02 ± 17.67 for the melatonin group and 44.85 ± 20.57 for the sertraline group. There was no significant difference in THI scores between the two groups (P = 0.23). After three months, the mean THI scores dropped significantly in both the melatonin group (30.29 ± 19.62) and the sertraline group (36.96 ± 25.03) (P < 0.01, for both).

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Furthermore, the melatonin group showed a significant decrease in THI score after treatment with 3 mg of melatonin once daily (P = 0.02).

4) Conclusion

Here in this scientific experiment, we showed that while melatonin and Zoloft are equally beneficial at treating tinnitus, the use of melatonin at a dosage of 3 mg once daily is more so.

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What will happen if you take Melatonin and Zoloft together?

When someone administers Zoloft (a specialized serotonin reuptake inhibitor) to you, you might wonder if it’s okay to take melatonin together with your antidepressant medications.

The possibility of experiencing certain adverse reactions, such as sedation, may rise if you combine melatonin with antidepressant medication. When taken together, melatonin and Zoloft may worsen side effects such as fatigue, confusion, and attention problems. In certain people, especially the elderly, thinking, making decisions, and motor function may also be compromised. 

Furthermore, avoid participating in activities like driving or operating potentially hazardous equipment until you have a better understanding of how drugs affect you. If you happen to have any inquiries or issues, consult your healthcare provider. 

I have some reservations about taking Melatonin and Zoloft together

We believe that taking sertraline and melatonin simultaneously may cause negative effects because there isn’t enough evidence available about the effects of combining both medications, even though each can be beneficial in addressing distinct issues.

Additionally, it is strongly discouraged to take sertraline and alcohol together. Alcohol might make you feel lightheaded, drowsy, and have trouble focusing, and can make the side effects of sertraline worse.

As has been previously stated, there isn’t much data to support the consequences of melatonin and zoloft combined. So, we are limited to speculation based on how each one functions alone.

How we reviewed this article

Trend Of Health has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. We avoid using tertiary references. You can learn more about how we ensure our content is accurate and current by reading our editorial policy

Drug Interactions between melatonin and Zoloft

Toxic optic neuropathy after concomitant use of melatonin, zoloft, and a high-protein diet

Tips To Help Manage Insomnia As A Side Effect Of Zoloft

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Fogari, et al. (2000, May). Cardiovascular effects of melatonin in hypertensive patients well controlled by Nifedipine: A 24-hour study. British journal of clinical pharmacology. Retrieved February 17, 2022,

Girardin, et al. (2014). Melatonin, the hormone of darkness: From sleep promotion to Ebola treatment. Brain disorders & therapy. Retrieved February 17, 2022,