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Can You Take Melatonin With Tylenol? Explained

- Written By

DR Mahnoor Chaudhary , Pharmacist

Updated on

This article is based on scientific evidence, written by experts and fact checked by experts. Our team of experts strive to be objective, unbiased, honest and to present both sides of the argument. This article contains scientific references. Read more about our process.

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Certainly the query, regarding can you take melatonin with tylenol?, has been resolved under various studies that found that combining these two medications resulted in improved pain control compared to using either medication alone.


However, it is always important to consult healthcare professionals before combining any medications.

Understanding The Combined Use Of Medications And Supplements

Since the origin of allopathic medicine, taking various drugs together has been consistent. In today’s fast-paced world, individuals managing multiple health conditions often prefer the convenience of taking their medications together instead of coordinating separate timings for each drug and considering the most frequently asked question these days regarding whether you can take melatonin with Tylenol. It’s important not to forget that every medicine comes with a few or more side effects, and imagine taking them together, which might interact in a way that’s harmful to your body.

Drugs undergo drug-drug and drug-food interactions; still, regarding the confusion related to melatonin and Tylenol, we initially need to understand potential interactions between medications and supplements to ensure safe usage. Here’s why it is crucial:

Safety Concerns: Certain substances may interact with each other in ways that alter their effectiveness and metabolism and increase the risk of toxicity.

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Efficacy: Some combinations may reduce the desired therapeutic effect, rendering the treatment less effective.

Dosing Considerations: Combining medications and supplements requires careful attention to dosing schedules and amounts. The wrongly calculated dosage could result in under-treatment or over-treatment, leading to adverse health outcomes.

Medical Conditions: Individuals with specific medical conditions like liver disease, kidney dysfunction, or cardiovascular issues may be more susceptible to medications and supplement interactions. Understanding these interactions becomes even more critical for such individuals as they might need additional monitoring or adjustments in their treatment plans.

Individuals can make informed choices under professional guidance by prioritizing a thorough understanding of potential interactions between medications and supplements. This approach promotes safe and effective usage while reducing the likelihood of adverse effects or compromised treatment outcomes.

Now, let’s dig deep to find the answer to can you take melatonin with tylenol?

What Is Melatonin? 

Melatonin, a hormone produced by your brain’s pineal gland in response to darkness and secreted into your body, helps regulate your circadian rhythms and sleep-wake cycles. Exposure to light may cease melatonin production. The brain’s production and release of melatonin fluctuates throughout the day, with levels increasing during nighttime hours and decreasing during daytime.

Notably, as individuals age, there is a decline in melatonin synthesis which can contribute to shorter sleep duration among older individuals. A perfect response to the query, “What does melatonin do?” is that by promoting better sleep duration and quality, melatonin can enhance overall restfulness and reduce nighttime awakenings. This can lead to improved daytime alertness and cognitive function.

It can be produced from microorganisms and animals, but synthetically produced melatonin supplements are the most common.

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Health Benefits Of Melatonin

1) Jet lag

It’s a temporary sleep disorder when individuals travel across multiple time zones, where the destination has a significant time difference from the origin, disrupting their body’s internal circadian rhythm. Individuals may experience symptoms such as fatigue, insomnia or excessive sleepiness at inappropriate times of day, difficulty concentrating, irritability, or digestive issues. In this situation, melatonin is crucial in regulating sleep-wake cycles and promoting healthy sleep patterns.

2) Delayed sleep-wake phase disorder (DSWPD)

People with DSWPD experience a significant delay in their internal body clock, causing them to naturally fall asleep and wake up later than desired or expected. Common symptoms include:

  • Difficulty falling asleep at night.
  • Excessive daytime sleepiness.
  • Feeling more alert during evening hours.
  • Struggling to wake up early despite adequate sleep duration.

Treatment options aim to adjust the sleep-wake schedule gradually and align it with societal norms. Melatonin helps signal to the body that it is time to sleep, making it beneficial for individuals with DSWPD.

3) Insomnia

Lastly, as we all know, the most commonly acquired sleep disorder among adults and old age people is insomnia.  

It is a sleep disorder characterized by difficulty falling asleep or staying asleep.

While melatonin primarily helps with initiating sleep, it also affects maintaining continuous sleep throughout the night, thus beneficial for people with insomnia. 

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Side Effects Of Melatonin

Melatonin is considered the safest among other sedatives as its prolonged usage doesn’t cause addiction or other life-threatening side effects. Along with the potential benefits, melatonin may cause:

  • Headache
  • Nausea
  • Dizziness
  • Irritability
  • Depression
  • Daytime sleepiness

Taking melatonin 2 hours before bedtime is usually recommended, which induces drowsiness and sleep, thus promoting faster and prolonged peaceful sleep patterns. 

What Is Tylenol?

Tylenol is a brand name for acetaminophen, an antipyretic and analgesic medication that helps reduce pain and fever by inhibiting certain chemicals in the body that contribute to them. It changes the way your body senses pain. It does not have anti-inflammatory properties like nonsteroidal anti-inflammatory drugs(NSAIDs), making it an alternative option for those who cannot tolerate NSAIDs due to allergies or other reasons.

Health Benefits Of Tylenol

Tylenol is widely used to alleviate mild to moderate pain, such as headaches, toothaches, muscle aches, backaches, arthritis pain, and menstrual cramps. Additionally, it can effectively reduce fever associated with common colds or flu-like illnesses. By lowering body temperature, it can help relieve discomfort and promote comfort during episodes of fever.

Side Effects Of Tylenol

Tylenol is generally considered safe when taken in prescribed dosages, but it may cause side effects in few people, including:

  • Nausea
  • Vomiting
  • Stomach pain
  • Loss of appetite
  • Headache
  • Insomnia

Can You Take Melatonin With Tylenol?

No known significant interactions are reported between Melatonin and Tylenol when taken at recommended doses. These two medications work differently in the body and do not interact with each other in a harmful way. Combining them can potentially increase the risk of specific side effects. These may include:

  • Dizziness
  • Drowsiness 
  • Difficulty Concentrating
  • Impaired Coordination 

 When taking both medications simultaneously, it’s essential to be aware of these possible effects. As always, it is recommended to consult with healthcare professionals for personalized advice based on your specific circumstances.

It’s worth noting that while acetaminophen is generally considered safe when used appropriately, excessive use may increase the risk of liver damage. Similarly, melatonin is a hormone produced by the body, but taking additional melatonin supplements excessively causes lightheadedness, nausea, and drowsiness may occur. It is crucial to adhere to recommended dosages and avoid exceeding the maximum daily limit of melatonin or Tylenol.

By seeking guidance from healthcare professionals, you can ensure that using melatonin and Tylenol together is appropriate for your situation without welcoming any potential risks or adverse effects.

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Factors To Consider Before Combining Melatonin And Tylenol

Suppose you’re still wondering, can you take melatonin with tylenol?. In that case, you need to consider the following factors before combining both: 

Individual Health Conditions: Certain health conditions may affect the safety or effectiveness of combining melatonin and Tylenol. For example, individuals with liver disease or impaired liver function should take precautions when using acetaminophen medications due to the potential risk of further liver damage.

Medication Dosages: It’s essential to consider the recommended dosages for melatonin and Tylenol individually and any maximum daily limits specified by healthcare professionals. Exceeding these can increase the risk of adverse reactions.

Age Groups: Different age groups may have varying tolerances and effectiveness for melatonin and Tylenol. Pediatrics, elderly individuals, or those with specific medical conditions may require dosage adjustments or additional monitoring when using these medications together.

Pregnancy/Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, it’s important to discuss medication use with a healthcare professional before combining melatonin and Tylenol. Tylenol is generally considered safer than other painkillers during pregnancy.

Consult Healthcare Professionals: It is always advisable to consult your healthcare provider or pharmacist before combining melatonin and Tylenol or any other medications. They can help determine if there are contraindications, potential interactions, and risks of adverse effects and also guide in making worthy decisions about medication use.

By considering these factors and seeking professional guidance, you can make informed decisions about the combination of melatonin and Tylenol appropriate for your situation.

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Expert Recommendations & Studies 

While there have been limited studies investigating the valid answer to can you take melatonin with tylenol? one of them is mentioned below :

A study published in the National Library of Medicine 2018 examined the Efficacy of the Preoperative Administration of Acetaminophen and Melatonin on Retrobulbar Block Associated Pain in Cataract Surgery. The study found that combining these two medications improved pain control compared to using either drug alone, with no significant adverse effects reported.


Melatonin may cause headaches, nausea, dizziness, depression, and daytime sleepiness. 

Tylenol may cause nausea, vomiting, loss of appetite, insomnia, and headache.

No known significant interactions are reported between Melatonin and Tylenol when taken at recommended doses. These two medications work differently in the body and do not interact with each other in a harmful way.

Melatonin dosages start from 2mg; the maximum daily dose should not exceed 10mg. Moreover, elderly patients have low levels of melatonin production in their bodies, thus responding to melatonin more sensitively. Consider giving them a relatively low dose by your pharmacist’s recommendation.

It’s considered safe if taken according to the recommended dose in consultation with your healthcare provider.

the bottom line

No known significant interactions exist between melatonin and Tylenol when taken at recommended doses. A most appropriate conclusion to the mystery of can you take melatonin with tylenol? is that these medications work differently in the body and typically do not interact. However, it is always advisable to consult healthcare professionals before combining any new medicines, including melatonin and Tylenol.

They can provide personalized advice based on individual health conditions, medication dosages, age groups, pregnancy/breastfeeding status, and other relevant factors. Moreover, Individuals with liver disease or impaired liver function should be conscientious when using acetaminophen medications due to the potential risk of further liver damage.

How we reviewed this article

Trend Of Health has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. We avoid using tertiary references. You can learn more about how we ensure our content is accurate and current by reading our editorial policy

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